Mechanisms of lipid metabolism in uterine receptivity and embryo development
发布于: 2023-08-28 来源: 国家饲料工程技术研究中心
摘要：Metabolic regulation plays important roles in embryo development and uterine
receptivity during early pregnancy, ultimately influencing pregnancy efficiency
in mammals. The important roles of lipid metabolism during early pregnancy
have not been fully understood. Here, we described the regulatory roles of phospholipid, sphingolipid, and cholesterol metabolism on early embryo development, implantation, and uterine receptivity through production of cannabinoids,
prostaglandins, lysophosphatidic acid, sphingosine-1-phosphate, and steroid
hormones. Moreover, the impacts of lipids and fatty acids on embryo development potential and the related epigenetic modifications are also discussed.
This review aims to elucidate the modulations of lipid metabolism on uterine receptivity and embryo development, contributing to novel strategies to establish
dietary balanced lipids and fatty acids for reducing early embryo loss.